Spot trading means you’re not technically “buying” the cryptocurrency, but instead trading your USD for it through either a market or a limit order. A market order means you agree to trade for the currency at the current market price. A limit order lets you put in a designated price at which you want the trade to occur, and when the currency reaches that price, the trade happens automatically. These orders then incur “maker” (for limit orders) or “taker” (for market orders) fees — though on Binance.US, there’s just a standard 0.1% fee.
Besides these broader differences, there are also some practical differences when comparing Binance vs Binance.US.

Binance currently lists 150 coins and tokens. Binance.US has said it is considering 30 assets to list initially. In a blog post last week, Coley acknowledged that "the ease of issuing blockchain tokens and the perceived lack of regulation could make these tokens targets for abuse," and that the company recognizes it has legal and moral obligations to protect its users.
4JNET’s unique mechanism echoes with the “HODL” idea of encrypted tokens to a great extent, which advocates “buy and hold” regardless of its appreciation and depreciation in the short run. In essence, its fairness, security and transparency enhance investors’ confidence in holding the tokens for a long time or trading at the right time, allowing them to become rich one day.