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This is just one example, but it definitely highlights the difference between trading on Binance and Binance.US. Although small traders won't make much of an impact on either exchange, all else being equal, most traders would prefer to trade against the larger book, rather than the smaller one.
The cryptocurrency crane had continued trending higher this month after experiencing some volatility earlier on when they were trading at $0.0000065 but now hover around $0.0000045, which still makes it more profitable.